Bioengineering Smart Factory Overall Solution

Relying on its rich experience in processes, regulations, manufacturing, operations, and verification in the field of microbial fermentation and synthetic biology, Triowin integrates digital and intelligent application technologies to provide personalized overall solutions for fermentation and pharmaceutical companies of different sizes, covering everything from raw materials, warehousing, processes, manufacturing, quality, equipment maintenance to final products, forming an overall solution capability for the entire process of bioengineering smart factories.

The downstream granulation and packaging workshop is mainly responsible for converting the active substances obtained from the upstream fermentation into a stable final product form that is easy to store and use, including granulation, drying, mixing, packaging and other steps.

After fermentation is complete, a harvesting step is performed to separate the target product from the fermentation broth. This involves physical methods such as centrifugation and filtration to remove cell debris, unused raw materials and other impurities. Subsequently, the primary purification stage uses chromatography, ultrafiltration, extraction and other techniques to further improve the purity of the target product.

Granulation is the process of converting pure active substances into granular forms suitable for oral administration or further processing. Wet granulation is done by mixing the active ingredients with a binder, using a granulator to form a wet mass and then drying it into granules; dry granulation is done by directly bonding the powder into granules under high pressure; melt granulation is suitable for heat-stable materials, which are formed into granules by melting and spray cooling.

The wet granules obtained by drying and granulation need to go through a drying process to remove excess moisture, ensure product stability and prevent microbial growth. Drying technologies include fluidized bed drying, spray drying, etc., which can complete the drying task efficiently and quickly while maintaining the good shape of the granules. After drying, the granules need to be appropriately crushed and screened by granulation equipment to ensure that the particle size distribution meets the requirements.

In order to ensure that the ingredients of each tablet or package of medicine are uniform, the dried particles will enter the mixing process and be evenly mixed with excipients such as fillers and lubricants. Drugs that need to control the release rate or improve the taste will also be coated.

The Triowin packaging line can efficiently complete a series of operations such as metering, filling, sealing, labeling, etc. According to the nature of the drug, various forms such as bottle packaging, blister packaging, and strip packaging can be selected. During the entire packaging process, a sterile environment and quality control are essential to prevent contamination and meet GMP (Good Manufacturing Practice) standards.