"Red, orange, yellow, green, cyan, blue, purple, who holds the colorful ribbon and dances in the sky?" 

On the White Egret Island in November, the warm sun shines gently and the blue waves are bustling.

The city flower, bougainvillea, is in full bloom all over the city, without the slightest hint of the cold of winter.

Its flower language is "enthusiasm, perseverance, and tenacious progress".

It infects every traveler from the biological industry who comes to Xiamen.

From November 17th to 19th, the 65th National Pharmaceutical Machinery Expo and the 2024 (Autumn) China International Pharmaceutical Machinery Expo were held at the Xiamen International Expo Center. All 11 exhibition halls were fully occupied, and a synthetic biology technology exhibition area was set up in the newly opened conference center this year. More than ten international forums and exchange meetings were held concurrently.

The exhibition area of this year's Pharmaceutical Machinery Expo is 234,000 square meters, with over 12,000 booths, an increase of nearly 40% compared to the spring Expo. With nearly 2,200 exhibitors participating and a demand for nearly 20,000 booths, it fully demonstrates the resilience of the pharmaceutical equipment industry in maintaining its development during the market adjustment period, as well as the confidence of the vast number of pharmaceutical machinery professionals in future development!

The National Pharmaceutical Machinery Expo and China International Pharmaceutical Machinery Expo is committed to promoting the sustainable development of China's pharmaceutical equipment industry. It strives to create a high-quality business platform for display, sharing, communication and connection for the upstream and downstream of the industrial chain. Along with the rapid development of China's pharmaceutical equipment industry, after more than 30 years of meticulous cultivation in terms of professionalization, branding and internationalization, It has developed into the most influential flagship event in China's pharmaceutical equipment industry.

At this pharmaceutical machinery exhibition, Triowin brought a one-stop solution for the bioengineering industry, covering the entire chain of services from experimental small-scale trials, medium-scale trials to industrial production. Have in-depth communication with partners in the upstream and downstream of the industry's industrial chain to jointly promote the high-quality development of the industry.

According to relevant research, in recent years, synthetic biology has received increasing attention in the field of biopharmaceuticals. However, the stage when synthetic biology leaves the laboratory and moves towards industrial mass production is the "valley of death" for synthetic biology, and the risks increase with multi-level scale expansion. For bulk commodities, the production scale of back-end fermentation needs to reach the ten-thousand-ton level in order to obtain a certain market share and spread out the production cost. This means that there are many levels of scale up that the process scale-up needs to cross. From the test tubes and shaking flasks in the laboratory to the large containers in industrial production, it is not a linear amplification. It is impossible to achieve geometric similarity, hydrodynamic similarity, etc. simultaneously. Therefore, each step requires a deepening understanding of biological processes and an expansion of their applications. In a laboratory environment, production conditions are mostly controlled under ideal conditions, and there is no need to consider the limitations of pressure and energy consumption indicators for the treatment of the three wastes. However, industrial mass production has brought many new dimensions beyond the laboratory scenario, such as the interaction of cell groups in a complex bioreactor environment, the transfer of nutrients, oxygen, heat, etc. (material and liquid mixing, agitator design) The control of internal environmental conditions in reactors (such as temperature, humidity, oxygen, pH value, etc.) and the design of large-scale bioreactors will become of vital importance. Therefore, during the industrial mass production process, every link, from the cultivation conditions of microorganisms to the design of fermentation tanks, needs to be carefully adjusted; otherwise, a small mistake will cause incalculable cost losses in the amplification process.

In addition, technologies such as separation, extraction and purification after fermentation are one of the core competencies of biomanufacturing enterprises. The fermentation, separation and purification processes involved in synthetic biology share similarities with traditional biological fermentation. The fermentation broth is a complex multiphase system, containing cells, metabolic products, culture media, various proteins and inorganic salts, etc. The content of impurities is relatively high, and the separation of solids and colloidal substances dispersed in it is rather difficult. There are various separation and purification techniques after fermentation, including cell disruption technology, precipitation separation and purification technology, centrifugal separation and purification technology, membrane separation and purification technology, chromatography separation and purification technology, extraction technology, freeze-drying technology, etc. Reliable and efficient separation and purification technology is one of the core competencies of biomanufacturing enterprises. At the same time, finding the balance point between the purification process and the purity, biological activity, output and economy of the product, and achieving the optimization of the process, is also a point that enterprises need to explore and consider.

In the field of bioengineering, Triowin Intelligent is not only a supplier of high-performance biological fermentation equipment such as bioreactors, disc centrifuges, biological fermentators, rotary cone low-temperature concentration machines, and sterilizers, but also a one-stop provider of overall solutions for food and biological intelligent factories. At the exhibition, the system solutions for the bio-fermentation industry presented by Wodi Intelligent enabled customers and visitors to understand the professional industry applications and the vigorous "vitality" of innovation.

Triowin Intelligent looks forward to gathering with new and old friends as well as partners in Xiamen to jointly contribute to the construction of the entire biopharmaceutical industry chain and embrace new challenges, new opportunities and new developments.